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Page 1
Drug uptake and pharmacological modulation of drug sensitivity in leukemia by AQP9.
Bhattacharjee H, Carbrey J, Rosen BP, Mukhopadhyay R. Bhattacharjee H, et al. Biochem Biophys Res Commun. 2004 Sep 24;322(3):836-41. doi: 10.1016/j.bbrc.2004.08.002. Biochem Biophys Res Commun. 2004. PMID: 15336539
AQP9 was transfected into the chronic myelogenous leukemia cell line K562. ...The possibility of using pharmacological agents to increase expression of AQP9 gene delivers the promise of new therapies for the treatment of leukemia. ...
AQP9 was transfected into the chronic myelogenous leukemia cell line K562. ...The possibility of using pharmacological agents …
AQP9 (Aquaporin 9) Determines Arsenic Uptake and Tolerance in Human Hepatocellular Carcinoma Cells In Vitro.
Yao D, Liu S, Lian F, Xu X, Yang J, Chen R, Cao Y. Yao D, et al. Cureus. 2022 Jul 11;14(7):e26753. doi: 10.7759/cureus.26753. eCollection 2022 Jul. Cureus. 2022. PMID: 35967171 Free PMC article.
Arsenic-based therapeutic strategies, even though promising for acute promyelocytic leukemia (APL), are limited by arsenic-related toxic effect and resistance with unknown mechanisms. ...Furthermore, NaAsO(2) dramatically increases AQP9 and p38 phosphorylation, whic …
Arsenic-based therapeutic strategies, even though promising for acute promyelocytic leukemia (APL), are limited by arsenic-related to …
Difference in glycerol levels between leukemia and normal bone marrow stem cells.
Qin YS, Bu DX, Cui YY, Zhang XY. Qin YS, et al. Oncol Lett. 2014 Jul;8(1):169-174. doi: 10.3892/ol.2014.2142. Epub 2014 May 13. Oncol Lett. 2014. PMID: 24959239 Free PMC article.
In addition, AQP9 is permeable to glycerol and urea. The involvement of AQP9 in leukemia has not been fully delineated. It is proposed that abnormal proliferation of hematopoietic stem cells (HSCs) contributes to leukemia carcinogenesis. Therefore, the …
In addition, AQP9 is permeable to glycerol and urea. The involvement of AQP9 in leukemia has not been fully delineated. …
AQP9-induced cell cycle arrest is associated with RAS activation and improves chemotherapy treatment efficacy in colorectal cancer.
Huang D, Feng X, Liu Y, Deng Y, Chen H, Chen D, Fang L, Cai Y, Liu H, Wang L, Wang J, Yang Z. Huang D, et al. Cell Death Dis. 2017 Jun 22;8(6):e2894. doi: 10.1038/cddis.2017.282. Cell Death Dis. 2017. PMID: 28640255 Free PMC article.
Aquaporin-9 (AQP9) expression is associated with arsenic sensitivity in leukemia cells. ...Patients with high AQP9 expression had higher rate of disease-free survival (DFS) than those with low AQP9 expression. ...
Aquaporin-9 (AQP9) expression is associated with arsenic sensitivity in leukemia cells. ...Patients with high AQP9 expr …
Cell Cycle-Dependent Uptake and Cytotoxicity of Arsenic-Based Drugs in Single Leukemia Cells.
Zhou Y, Wang H, Tse E, Li H, Sun H. Zhou Y, et al. Anal Chem. 2018 Sep 4;90(17):10465-10471. doi: 10.1021/acs.analchem.8b02444. Epub 2018 Aug 21. Anal Chem. 2018. PMID: 30080396
Herein, we establish a methodology to evaluate the uptake of two arsenic-based drugs (ATO and ZIO-101) across the cell cycle in single leukemia cells, i.e., NB4 and HL60, using a double thymidine block combined with time-resolved inductively coupled plasma mass spectrometr …
Herein, we establish a methodology to evaluate the uptake of two arsenic-based drugs (ATO and ZIO-101) across the cell cycle in single le …
Arsenite transport by mammalian aquaglyceroporins AQP7 and AQP9.
Liu Z, Shen J, Carbrey JM, Mukhopadhyay R, Agre P, Rosen BP. Liu Z, et al. Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):6053-8. doi: 10.1073/pnas.092131899. Epub 2002 Apr 23. Proc Natl Acad Sci U S A. 2002. PMID: 11972053 Free PMC article.
The fps1Delta cells exhibit reduced transport of (73)As(III) or (125)Sb(III), but uptake is enhanced by expression of AQP9. Xenopus laevis oocytes microinjected with either AQP7 or AQP9 cRNA exhibited increased transport of (73)As(III). These results suggest that …
The fps1Delta cells exhibit reduced transport of (73)As(III) or (125)Sb(III), but uptake is enhanced by expression of AQP9. Xenopus l …
Relationship of expression of aquaglyceroporin 9 with arsenic uptake and sensitivity in leukemia cells.
Leung J, Pang A, Yuen WH, Kwong YL, Tse EW. Leung J, et al. Blood. 2007 Jan 15;109(2):740-6. doi: 10.1182/blood-2006-04-019588. Epub 2006 Sep 12. Blood. 2007. PMID: 16968895 Free article.
Arsenic trioxide (As2O3) is highly efficacious in acute promyelocytic leukemia (APL). Aquaglyceroporin 9 (AQP9) is a transmembrane protein that may be involved in arsenic uptake. ...Similarly, the chronic myeloid leukemia line K562 expressed low levels of …
Arsenic trioxide (As2O3) is highly efficacious in acute promyelocytic leukemia (APL). Aquaglyceroporin 9 (AQP9) is a transmemb …
Aquaporin 9, a promising predictor for the cytocidal effects of arsenic trioxide in acute promyelocytic leukemia cell lines and primary blasts.
Iriyama N, Yuan B, Yoshino Y, Hatta Y, Horikoshi A, Aizawa S, Takeuchi J, Toyoda H. Iriyama N, et al. Oncol Rep. 2013 Jun;29(6):2362-8. doi: 10.3892/or.2013.2388. Epub 2013 Apr 5. Oncol Rep. 2013. PMID: 23563754
Thus, in the present study, the correlation between the expression levels of AQP9 and sensitivity to ATO was investigated using two acute promyelocytic leukemia (APL) cell lines, NB4 and HT93A, as well as primary APL cells from newly diagnosed and relapsed APL patie …
Thus, in the present study, the correlation between the expression levels of AQP9 and sensitivity to ATO was investigated using two a …
Granulocyte colony-stimulating factor potentiates differentiation induction by all-trans retinoic acid and arsenic trioxide and enhances arsenic uptake in the acute promyelocytic leukemia cell line HT93A.
Iriyama N, Yuan B, Hatta Y, Horikoshi A, Yoshino Y, Toyoda H, Aizawa S, Takeuchi J. Iriyama N, et al. Oncol Rep. 2012 Nov;28(5):1875-82. doi: 10.3892/or.2012.2006. Epub 2012 Aug 31. Oncol Rep. 2012. PMID: 22940758
Addition of 1 M ATRA and/or 50 ng/ml G-CSF to ATO did not affect apoptosis compared to ATO treatment alone. ATRA induced expression of aquaporin-9 (AQP9), a transmembrane transporter recognized as a major pathway of arsenic uptake, in a time- and dose-dependent manner. How …
Addition of 1 M ATRA and/or 50 ng/ml G-CSF to ATO did not affect apoptosis compared to ATO treatment alone. ATRA induced expression of aquap …
Azacytidine sensitizes acute myeloid leukemia cells to arsenic trioxide by up-regulating the arsenic transporter aquaglyceroporin 9.
Chau D, Ng K, Chan TS, Cheng YY, Fong B, Tam S, Kwong YL, Tse E. Chau D, et al. J Hematol Oncol. 2015 May 8;8:46. doi: 10.1186/s13045-015-0143-3. J Hematol Oncol. 2015. PMID: 25953102 Free PMC article.
The mechanism of AQP9 up-regulation was then investigated by examining the expression of transcription factors for AQP9 gene and the methylation status of their gene promoters. ...AQP9 promoter does not contain CpG islands. Instead, azacytidine pre-treatment …
The mechanism of AQP9 up-regulation was then investigated by examining the expression of transcription factors for AQP9 gene a …
15 results